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Vera Ortseifen Selected Research

Acarbose

11/2020The expression of the acarbose biosynthesis gene cluster in Actinoplanes sp. SE50/110 is dependent on the growth phase.
11/2017The complete genome sequence of the actinobacterium Streptomyces glaucescens GLA.O (DSM 40922) carrying gene clusters for the biosynthesis of tetracenomycin C, 5`-hydroxy streptomycin, and acarbose.
6/2017Genome improvement of the acarbose producer Actinoplanes sp. SE50/110 and annotation refinement based on RNA-seq analysis.
1/2017The MalR type regulator AcrC is a transcriptional repressor of acarbose biosynthetic genes in Actinoplanes sp. SE50/110.
8/2016Genetic engineering in Actinoplanes sp. SE50/110 - development of an intergeneric conjugation system for the introduction of actinophage-based integrative vectors.
1/2016Comparative proteome analysis of Actinoplanes sp. SE50/110 grown with maltose or glucose shows minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters.
7/2015Comprehensive proteome analysis of Actinoplanes sp. SE50/110 highlighting the location of proteins encoded by the acarbose and the pyochelin biosynthesis gene cluster.
1/2015Complete genome sequence of the actinobacterium Streptomyces glaucescens GLA.O (DSM 40922) consisting of a linear chromosome and one linear plasmid.
12/2014Carbon source dependent biosynthesis of acarviose metabolites in Actinoplanes sp. SE50/110.

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Vera Ortseifen Research Topics

Disease

7Type 2 Diabetes Mellitus (MODY)
11/2017 - 12/2014
2Diabetes Mellitus
11/2020 - 01/2015

Drug/Important Bio-Agent (IBA)

9AcarboseFDA LinkGeneric
11/2020 - 12/2014
3Pharmaceutical PreparationsIBA
11/2020 - 07/2015
2GlucosidasesIBA
08/2016 - 07/2015
2CarbonIBA
01/2016 - 12/2014
2Glucose (Dextrose)FDA LinkGeneric
01/2016 - 12/2014
2MaltoseIBA
01/2016 - 12/2014
1Glycoside Hydrolase InhibitorsIBA
01/2015
1Galactose (Galactopyranose)FDA LinkGeneric
12/2014